Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.370 | GeneticVariation | disease | BEFREE | The BRAF mutation was not detected in PC. | 26927447 | 2016 | ||||
|
0.370 | AlteredExpression | disease | BEFREE | These deletions are mutually exclusive with KRAS mutations and occur in 4.21% of KRAS wild-type pancreatic cancer. siRNA knockdown in cells harboring BRAF deletions showed that the MAPK activity and cell growth are BRAF dependent. | 26732095 | 2016 | ||||
|
0.370 | GeneticVariation | disease | BEFREE | KRAS, NRAS and BRAF mutations are among the most important oncogenic drivers in many major cancer types, such as melanoma, lung, colorectal and pancreatic cancer. | 29059158 | 2018 | ||||
|
0.370 | AlteredExpression | disease | BEFREE | In the present work, we explored the carcinogenic activity and underlying mechanism of BRAF-activated noncoding RNA on pancreatic cancer <i>in vitro</i>. | 31769353 | 2020 | ||||
|
0.370 | GeneticVariation | disease | BEFREE | Both BRAF and FBXW7 mutations functionally activate kinase effectors important in pancreatic cancer and extend the potential options for therapeutic targeting of kinases in the treatment of phenotypically distinct pancreatic adenocarcinoma subsets. | 14507635 | 2003 | ||||
|
0.370 | GeneticVariation | disease | BEFREE | Oncogene-directed increased expression of Nrf2 is a new mechanism for the activation of the Nrf2 antioxidant program, and is evident in primary cells and tissues of mice expressing K-Ras(G12D) and B-Raf(V619E), and in human pancreatic cancer. | 21734707 | 2011 | ||||
|
0.370 | GeneticVariation | disease | BEFREE | We investigated the frequency of BRAF mutations in human pancreatic cancer specimens to determine its role in the development of pancreatic cancer. | 12969789 | 2003 |